Neutron based measurements are well established in colloidal science and studies of synthetic polymers and complex fluids. More recent interests have included fundamental biophysical studies in protein structure and assembly, but many researchers in biochemistry, applied biophysics, and the biotechnology industry remain relatively unfamiliar with the range of neutron-based techniques and their ability to answer questions about macromolecule structure, morphology, and dynamics in bulk solution and at interfaces. This inaugural meeting is intended to provide a venue for students and established researchers to learn about the application of neutron science to fundamental biophysical studies proteins and other biological macromolecules, with a long-term view of enhancing the use of these techniques in biotechnology applications. A post-conference workshop will provide lectures on the fundamentals of neutron scattering and reflectivity. The conference will consist of a series of lectures by established experts in biotechnology topics, including, but not limited to: self assembly of biological molecules; protein structure, dynamics, and interactions; aggregation and phase behaviour; biomolecule adsorption to interfaces; hydration and interactions with co-solutes.
The long terms goal of these meetings (which will run at least bi-annually) will be to give biotechnology students an introduction to neutron scattering techniques as well as making biotech industry aware of the potential benefits of these techniques.
The main themes of the conference will include:
Applications of the neutron scattering to biotechnology – fundamental vs. applied science.
Giving details of the process by which experimental time is obtained and conducted.
General topic areas will be more will be related to industrial applications.
The following keynote speakers are confirmed:
Dr Paul Butler, NIST, USA
Insights into membrane thickness fluctuations
Dr Marcus Cicerone, NIST, USA
How can picosecond dynamics predict protein stability in a glassy matrix?
Prof Jeremy Lakey, Newcastle University, UK
Neutron Reflectivity Measurements of Biosensor Interfaces
Prof Jian Lu, University of Manchester, UK
Molecular basis of surface biocompatibility as studied by neutron reflection and scattering
Dr Sylvia Mclain, University of Oxford, UK
Biological aggregation: insights from atomic level measurements in solution
Prof Steve Perkins, UCL, UK
Atomistic modelling of SANS and SAXS data in applications to diverse antibody classes important in biotechnology and disease
Dr Peter Schurtenberger, Lund University, Sweden
Protein interactions, stability and phase behavior – insight from neutron scattering experiments
The conference will be held at Cosener’s House, 15-16 Abbey Close, Abingdon, Oxfordshire OX14 3JD, UK, with accommodation being available on-site and at nearby hotels. Abingdon is close to Oxford and about 1 hour from London. Accommodation and travel advice is given under Local Information.
Registration and payment is through the conference website, see Registration.
With accommodation £250
Without accommodation £100
Training and Orientation at ISIS (5th September) £40
Abstract Submission Deadline:
Oral Presentations 31st July
Poster Presentations 31st July
The organising committee would like to take this opportunity to warmly welcome you to what we hope will be a very stimulating inaugural meeting.
On behalf of the NCFAB Symposium Organising Committee
Daniel G. Bracewell, University College London
Christopher J. Roberts, University of Delaware
Luke Clifton, ISIS, STFC, Rutherford Appleton Laboratory
Ann Terry, ISIS, STFC, Rutherford Appleton Laboratory